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Cornell University

Post-translational modifications (PTM)

Our full service includes sample preparation, sample analysis and data interpretation. If you want to do the sample preparation or data interpretation yourself, let us know during the project consultation.

The service fees are broken down in the tables below.

Service pricing

Sample preparation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Bradford Assay (set up) $40 $65.60
Bradford Assay (per sample) $6 $9.84
Affinity depletion of serum high abundant proteins by column (per sample) $120 $192
Affinity depletion of serum high abundant proteins by ProteoMiner (per sample) $70 $114.80
Proteominer Supplies $90 $147.60
TMT 6-plex reagent (per set of samples) $380 $623.20
TMT 6-plex labeling and sample preparation (per set of samples) $650 $1066
TMT 10-plex reagent (per set of samples) $750 $1,230
TMT 10-plex labeling and sample preparation (per set of samples) $860 $1,410.40
TMT 11-plex reagent (per set of samples) $880 $1,443.20
TMT 11-plex labeling and sample preparation (per set of samples) $950 $1,558
TMT 16-plex reagent (per set of samples) $1,100 $1,804
TMT 16-plex labeling and sample preparation (per set of samples) $1,300 $2,132
TMT 18-plex reagent (per set of samples) $1300 $2132
TMT 18-plex labeling and sample preparation (per set of samples) $1500 $2460
Gel-based protein quantitation for shotgun 10-15 well (per set of samples) $200 $328
Gel-based protein quantitation for shotgun 26 well (per set of samples) $300 $492
dimethylation duplex labeling (per set of samples) $350 $574
dimethylation triplex labeling (per set of samples) $500 $820
mini SDS-PAGE (precast, 10-15 well) running, stain and imaging (per gel) $150 $246
mini SDS-PAGE (precast, 26 well) running, stain and imaging (per gel) $235 $385.40
Gel Imaging on ChemiDoc (per hour) $65 $106.6
In-gel Digest/Extraction, manual (set up) $100 $164
In-gel Digest/Extraction plus filtration, manual (per sample) $70 $114.80
In-solution digestion (set up) $100 $164
In-solution digestion (per sample) $55 $90.20
Strap-Based (micro) in-solution digestion (100ug) per sample $75 $123
Strap-Based (mini) in-solution digestion (100ug-300ug) per sample $90 $147.60
Strap-Based (midi) in-solution digestion (>300ug) per sample $110 $180.40
SPE Cleanup, manual (per sample) $30 $49.20
Beads-based IMAC or TiO2 enrichment (per sample) $100 $164
MCX/MAX Cartridge (manual) (per sample) $70 $114.80
Other beads-based affinity enrichment (per sample) $80 $131.20
HRP Cartridge manual fractionation (per sample) $100 $160
Sample Prep Optimization (non SOP) per hour $70 $114.80
HPLC/MS
DescriptionInternal price (Cornell and Cornell affiliates)External price
Ion exchange chromatography with fractions collection (per sample) $300 $492
high pH reverse phase with fractions collection (per sample) $300 $492
HILIC chromtography with fractions collection (per sample) $300 $492
nanoLC-MS/MS: 90-120min gradient in Orbitrap Fusion/Eclipse (per sample) $250 $410
nanoLC-MS/MS: 90-120min gradient in Orbitrap Eclipse RTS MS3 (per sample) $275 $451
LC/MS/MS for protein PTMs in two runs (CID/HCD/ETD) (per sample) $215 $352.60
Hypothesis-driven LC-MS/MS run for PTM discovery in QTrap (per sample) $175 $287
Infusion ESI-MS/MS for protein IDs and PTMs (per sample) $130 $213.20
nanoLC-MS/MS: Method development & optimization for specific PTMs $250 $410
Target-based LC-MS/MS run for protein IDs or quan or PTMs $300 $492
HPLC/MS data interpretation
DescriptionInternal price (Cornell and Cornell affiliates)External price
Peptide quantitation by extracted ion chromatogram (per hour) $165 $270.60
MS/MS manual data interpretation and inspection (per hour for all relevant spectra) $165 $270.60
Quantitation analysis for label-free nanoLC-MS/MS (per set of quan) $150 $246
Customized database interrogation (per database) $80 $131.20
LC/MS spectra slides or figures for presentation/mansucript (per hour) $290 $475.60
Database search against an additional database (per hour) $80 $131.20
Database search training (per hour) $165 $270.60
Database search and report for externally generated raw data files (per search) $225 $369
Raw & result files uploading to public database (PRIDE, Metabolights) $450 $738